Na+-Ca2+Exchange Current and Submembrane [Ca2+] During the Cardiac Action Potential
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چکیده
منابع مشابه
Na(+)-Ca(2+) exchange current and submembrane [Ca(2+)] during the cardiac action potential.
Na(+)-Ca(2+) exchange (NCX) is crucial in the regulation of [Ca(2+)](i) and cardiac contractility, but key details of its dynamic function during the heartbeat are not known. In the present study, we assess how NCX current (I(NCX)) varies during a rabbit ventricular action potential (AP). First, we measured the steady-state voltage and [Ca(2+)](i) dependence of I(NCX) under conditions when [Ca(...
متن کاملNa-Ca Exchange Current and Submembrane [Ca] During the Cardiac Action Potential
Na-Ca exchange (NCX) is crucial in the regulation of [Ca]i and cardiac contractility, but key details of its dynamic function during the heartbeat are not known. In the present study, we assess how NCX current (INCX) varies during a rabbit ventricular action potential (AP). First, we measured the steady-state voltage and [Ca]i dependence of INCX under conditions when [Ca ]i was heavily buffered...
متن کاملPotential ] during the Cardiac Action 2+ Exchange Current and Submembrane [ca 2+ -ca + Na
Na -Ca exchange (NCX) is crucial in the regulation of [Ca ]i and cardiac contractility, but key details of its dynamic function during the heartbeat are not known. In the present study, we assess how NCX current (INCX) varies during a rabbit ventricular action potential (AP). First, we measured the steady-state voltage and [Ca ]i dependence of INCX under conditions when [Ca 2 ]i was heavily buf...
متن کاملProfile of L-type Ca(2+) current and Na(+)/Ca(2+) exchange current during cardiac action potential in ventricular myocytes.
OBJECTIVE The L-type Ca(2+) current (I(Ca,L)) and the Na(+)/Ca(2+) exchange current (I(NCX)) are major inward currents that shape the cardiac action potential (AP). Previously, the profile of these currents during the AP was determined from voltage-clamp experiments that used Ca(2+) buffer. In this study, we aimed to obtain direct experimental measurement of these currents during cardiac AP wit...
متن کاملThe role of Na-Ca exchange current in the cardiac action potential.
Since 1981, when Mullins published his provocative book proposing that the Na-Ca exchanger is electrogenic, it has been shown, first by computer simulation by Noble and later by experiment by various investigators, that inward iNaCa triggered by the Ca2+ transient is responsible for the low plateau of the atrial action potential and contributes to the high plateau of the ventricular action pote...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2002
ISSN: 0009-7330,1524-4571
DOI: 10.1161/hh0202.103940